Primary pfs analysis
WebApr 13, 2024 · According to our multivariate regression analysis, platinum sensitivity is an independent factor influencing PFS in the RT group. 65.6% (21/32) of the patients received less than three lines of chemotherapy were platinum-sensitive, compared with a platinum sensitivity rate of 34.8% (16/46) for patients with three or more lines of previous … WebMethods Systematic literature review and meta-analysis to compare PTR versus primary tumor intact (PTI). Results Seventy-seven studies were included, reporting on 159,991 …
Primary pfs analysis
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WebAt the primary PFS analysis (May 22, 2024; median follow-up, 14.8 mo), APP exhibited significant PFS improvement versus PP (median = 7.6 versus 5.2 mo, stratified hazard … Webpreferred to change the primary analysis from 122 PFS events to144 PFS events, FDA would consider the primary objective fulfilled only if tests at both 122 and 144 PFS events were statistically significant. 2. There were two versions (version 1.0 and version 1.1) of statistical analysis plan (SAP) for Study GRID in the NDA submission.
WebApr 13, 2024 · 3.5. Comparison of the OS and PFS. The PFS of the two groups of patients is shown in Figure 1, and the OS is shown in Figure 2.The median PFS of the control group was 13.4 months (95%CI: 6.5 to 17.6), and the median PFS of the study group was 15.6 months (95%CI: 12.4 to 23.1); there was no significant difference in the PFS between the two … WebJan 22, 2024 · IMpower131: Primary PFS and Safety Analysis of a Randomized Phase III Study of Atezolizumab + Carboplatin + Paclitaxel or Nab-Paclitaxel vs Carboplatin + Nab …
WebMar 22, 2024 · double-blind study treatment. At the time of the primary PFS analysis with a median follow-up of 13.2 months, the approximately 300-event target to trigger the final OS analysis had not been reached; a prespecified interim anal-ysis of the difference in OS was conducted by the data monitoring committee but was not statistically significant. WebApr 10, 2024 · Introduction Primary breast lymphoma (PBL) is a rare disease, treatment of which excerpts does not reach a consensus. This retrospective study was conducted to analyze clinical features and survival outcomes of different therapeutic methods. Materials and methods Records of 67 patients with stage IE/IIE primary breast lymphoma were …
WebNov 20, 2024 · The primary end point was 1-year progression-free survival (PFS), with a target improvement compared with historical data of at least 15%, from 45% to 60%. To test this efficacy hypothesis, a sample size of 74 assessable patients provided a power of 83% with a one-sided alpha of 5%.
WebApr 14, 2024 · Median PFS was 6.7 months, 9.0 months, not reached, not evaluable, 9.5 months, 5.5 months, not ... The primary analysis cohort enrolled a maximum of 25 … how to make your turkey moistWebAug 30, 2024 · At the pre-specified interim analysis, the phase 3 KarMMa-3 trial (NCT03651128) met its primary end point of statistically significantly improved progression-free survival when patients with relapsed/refractory multiple myeloma who had previously received 2 to 4 prior lines of therapy and were refractory to their last regimen were treated … how to make your tv bluetoothWebApr 11, 2024 · Firstly, univariate analysis was applied to test individual effect of each variable on PFS in primary cohort. The associations between PFS and T-stage, N-stage, total stage, age, gender and other factors were analyzed by Cox proportional hazard regression model afterwards. how to make your turkey brownWebJun 3, 2024 · The primary PFS analysis was to be performed after observing approximately 364 local PFS events to detect a hazard ratio of 0.67 with 95% power and a one-sided … how to make your tv a 2nd screen for laptopWebprimary PFS analysis. For OS, a modified linear alpha-spending function will be used to determine the alpha level at 3 analyses. The alpha level will be 0.0001 for the first OS … how to make your tv look like a mirrorWebApr 10, 2024 · Introduction Primary breast lymphoma (PBL) is a rare disease, treatment of which excerpts does not reach a consensus. This retrospective study was conducted to … how to make your tv look like a pictureWeb• Primary endpoint: PFS • Submitted sensitivity analysis: Censor patients at last assessment prior to 1. NALT (purpose: NALT might be indicative of PD) 2. First missing visit if they had ≥2 missing visits prior to PD or death (purpose: PD might have happened during the time when patient missed visits) Robust assessment of treatment effect. mukesh bhatt wife