Oxiapoptophagy

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August undefined, 2024

WebJul 19, 2024 · Oxysterols increase in abundance in tissue and plasma with age, and Nury et al. discuss the potential of these elevated oxysterol levels, specifically 7-KC, 7β-HC and 24S-HC, to induce a type of cell death defined as ‘oxiapoptophagy’, associated with oxidative stress, apoptosis and autophagy. Pharmacological inhibitors of oxiapoptophagy ... WebJan 14, 1999 · 1.1 Oxysterols. Oxysterols are 27-carbon derivatives of cholesterol, or by-products of cholesterol biosynthesis, that contain additional oxygen functions as hydroxyl, carbonyl, or epoxide groups (Schroepfer, 2000 ). Generally, introduction of an oxygen function in cholesterol markedly reduces its half-life and directs it to excretion or to ...

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WebSep 15, 2024 · Oxiapoptophagy involving oxidative stress, autophagy, and apoptosis can be induced by 7KC. However, whether 7KC produces negative effects on MC3T3-E1 cells by … WebMar 24, 2024 · 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells Jing Ouyang, Yaosheng Xiao, +7 authors Longhuo Wu … lakeland pans uk

oxiapoptophagy - Wiktionary

WebBased on these di erent characteristics, 7KC-induced cell death has been deﬁned as oxiapoptophagy (OXIdative stress +APOPTOsis +autoPHAGY) [40,41]. In human aortic smooth muscle cells,... WebJul 26, 2024 · The term oxiapoptophagy (OXIdative stress + APOPTOsis + autoPHAGY) firstly reported by Monier and coworkers [ 41 ], was later described to be induced by other … WebOxiapoptophagy has also been described on 7KC-treated bone marrow mesenchymal stem cells from patients with acute myeloid leukaemia (Paz et al., 2024). Notably, in these … jeneva hakman

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol …

(PDF) 25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 …

WebNov 15, 2024 · Oxiapoptophagy involving oxidative stress, autophagy, and apoptosis can be induced by 7KC. However, whether 7KC produces negative effects on MC3T3-E1 cells by stimulating oxiapoptophagy is still unclear. In the current study, 7KC was found to significantly decrease the cell viability of MC3T3-E1 cells in a concentration-dependent … WebApr 11, 2014 · As 7KC induces numerous side effects (oxidative stress, inflammatory processes, and cell death) [20], the term oxiapoptophagy [12] was suggested to define the complex mode of cell death induced by 7KC on U937 cells including oxidative stress, apoptosis, and probably also autophagy [13]. jeneva coulanderWebThus, in N2a cells, 7KC induces a mode of cell death by oxiapoptophagy, including criteria of OXIdative stress, APOPTOsis and autoPHAGY, associated with mitochondrial and peroxisomal dysfunction, which is counteracted by RSV, QCT, and API reinforcing the interest for these polyphenols in prevention of diseases associated with increased 7KC … lakeland pastry

"WebMay 1, 2024 · In the murine oligodendrocyte cell-line 158N, 7β-OHC triggers a complex mode of cell death defined as oxiapoptophagy. 7β-OHC induces oxidative stress associated with mitochondrial dysfunction, increased activity of major antioxidant enzymes (SOD, CAT and GPx), lipid and protein oxidation, modification of cholesterol and fatty acid metabolism ... " - Oxiapoptophagy

Oxiapoptophagy

WebApoptosis is associated with activation of the mitochondrial pathway, opening of the mitochondrial permeability pore, loss of mitochondrial membrane potential, caspase-3 activation, PARP degradation, nuclear condensation and/or fragmentation. WebNov 15, 2024 · AMA Style. Ghzaiel I, Nury T, Zarrouk A, Vejux A, Lizard G. Oxiapoptophagy in Age-Related Diseases. Comment on Ouyang et al. 7-Ketocholesterol Induces …

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WebJul 1, 2015 · Furthermore, the different cytotoxic effects associated with 7KC, 7β-OHC and 24S-OHC-induced oxiapoptophagy are attenuated by vitamin E (VitE, α-tocopherol) and DHA which enhances VitE protective effects. In 158N murine oligodendrocytes, our data support the concept that oxiapoptophagy, which can be inhibited by VitE and DHA, could be a ... WebMay 21, 2024 · In conclusion, oxiapoptophagy (OXIdative stress + APOPTOsis + autophagy) seems to be activated by 7-KC in LMSCs. More studies are needed to better understand the role of 7-KC in the death of LMSCs and the possible effects on the SHh pathway. Keywords: oxysterol, 7-KC, mesenchymal stem cell, apoptosis, autophagy, acute myeloid leukemia, …

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WebOxiapoptophagy is a cell death in which apoptosis, oxidative stress, and autophagy are combined. ... ... Previously, our studies reported the 25-HC-induced extrinsic and intrinsic apoptosis in... WebIn 158N murine oligodendrocytes, 7KC triggers a complex mode of cell death defined as oxiapoptophagy, involving simultaneous oxidative stress, apoptosis and autophagy.

WebJul 27, 2024 · In addition, inhibition of G-protein-coupled receptor 183 (GPR183), a receptor of 7α,25-DHC, using GPR183 specific antagonist NIBR189 suppressed 7α,25-DHC-induced …

WebJun 24, 2024 · Oxiapoptophagy: A type of cell death induced by some oxysterols T. Nury, A. Zarrouk, +3 authors G. Lizard Published 24 June 2024 Biology, Chemistry British Journal of Pharmacology Oxysterols are oxidized forms of cholesterol generated from cholesterol by auto‐oxidation, enzymatic processes, or both. lakeland parkingWebAttenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases T. Nury, A. Yammine, I. Ghzaiel, K. Sassi, ... lakeland paradeWeboxiapoptophagy ( uncountable ) ( biology) A combination of oxidation, apoptosis and autophagy associated with oxidative stress. This page was last edited on 30 January … lakeland partsWebMay 21, 2024 · In conclusion, oxiapoptophagy (OXIdative stress + APOPTOsis + autophagy) seems to be activated by 7-KC in LMSCs. More studies are needed to better understand … jeneva name meaningWebNov 15, 2024 · Oxiapoptophagy involving oxidative stress, autophagy, and apoptosis can be induced by 7KC. However, whether 7KC produces negative effects on MC3T3-E1 cells by … lakeland parkWebJul 1, 2024 · Oxiaptophagy is associated with organelle dysfunction and in particular with mitochondrial and peroxisomal alterations involved in the induction of cell death and in … jeneva ohan uwaWebJul 26, 2024 · Moreover, we confirmed that 5,6 α-EC and 5,6 β-EC induced oxiapoptophagy through concomitant oxidative stress and caspase-3-mediated apoptosis and autophagy. … lakeland patch