Irf8 genecards
WebMar 29, 2024 · Detroit, city, seat of Wayne county, southeastern Michigan, U.S. It is located on the Detroit River (connecting Lakes Erie and St. Clair) opposite Windsor, Ontario, … Web(Click on the icon in the table below to see search hit context)
Irf8 genecards
Did you know?
WebNov 17, 2024 · IRF8 R294C mice were crossed with C57BL/6 wild-type female for at least three generations to eliminate the vertical transmission of Murine Leukemia Virus (MuLV). Progenies were crossed to generate the mice carrying homozygous alleles for the mutation, and all the mice were used at the age of 8–12 weeks. WebIRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, [7] recent studies, however, …
WebIFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of … WebMar 10, 2011 · IRF8 is an essential transcriptional regulator of IFN-β expression in monocytes We hypothesized that IRF8, a transcription factor found only in lymphoid and myeloid cells such as macrophages, 24, 32 might be involved.
WebAug 24, 2024 · IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b + Gr1 + immature myeloid cells (IMCs), particularly the CD11b + Ly6C hi/+ Ly6G - polymorphonuclear myeloid-derived suppressor cell-like cells (PMN-MDSCs). WebAug 8, 2024 · IRF8 is a key regulator of innate immunity receptor signaling and plays diverse functions in the development of hematopoietic cells. The effects of IRF8 on hematopoietic stem cells (HSCs) are still unknown. Here, it is demonstrated that IRF8 deficiency results in a decreased number of long-term HSCs (LT-HSCs) in mice.
WebThe strengths of this test include: CAP accredited laboratory; CLIA-certified personnel performing clinical testing in a CLIA-certified laboratory
WebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … easter guided readingWebFeb 15, 2008 · IRF8 binds to certain DNA motifs such as ISRE and Ets/IRF composite elements by interacting with partner proteins that include IRF members and Ets family proteins. 12, 15 Although IRF8 can regulate gene expression through other mechanisms, the interaction with partners is thought to be a critical requirement for macrophage … cuddle fleece whiteWebNov 15, 2008 · IRF8 is known to bind to any of 4 distinct target sequences in genes subject to transcriptional activation or repression by IRF8. 29 Studies of the regulatory sequences of Sfpi1, which encodes PU.1, identified 2 possible IRF8 target sites. cuddle fleece back cushionWebSep 20, 2016 · Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional … easter hairstyles for long hairWebDetroit is a city located in Wayne County Michigan.It is also the county seat of Wayne County.With a 2024 population of 621,193, it is the largest city in Michigan and the 27th … cuddle fleece wrap blanketWebMar 21, 2024 · IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma. Global assessment of IRF8 as a novel cancer biomarker. Predicting the … easter half term 2021WebInterferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. [5] [6] [7] IRF8 is … easter hairstyles for black girls