Foxa3 macrophage
WebDec 12, 2024 · Overall, these data suggest that FOXO3 inactivation in macrophages enhances IL-10 expression, leading to a modulated … WebAug 11, 2006 · The Foxa subfamily of winged helix/forkhead box (Fox) transcription factors has been the subject of genetic and biochemical study for over 15 years.During this time its three members, Foxa1, Foxa2 and Foxa3, have been found to play important roles in multiple stages of mammalian life, beginning with early development, continuing during …
Foxa3 macrophage
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WebObjective: To determine the role of hepatic FOXA3 (forkhead box A3) in lipid metabolism and atherosclerosis. Approach and Results: Hepatic FOXA3 expression was reduced in … WebApr 19, 2024 · FOXA3 plays in macrophage cholesterol efflux and its possible association with insulin resistance, obesity, and atherosclerosis, we consider it interesting to carry out studies on the association of polymorphisms of this gene with cardiovascular diseases and metabolic parameters. Thus, the present study aimed to evaluate the association of two ...
WebJul 1, 2024 · (B) Expression of Foxa3, Hnf4α, and Clec4f in non-parenchymal cells (NPC) and mouse primary hepatocytes (MPH) (n = 3). (C) Average UMI counts of Foxa3 in … WebHere we report that Foxa3 is required for the maintenance of glucose homeostasis during a prolonged fast and for the metabolic regulation of the hepatic transcription factor network. We also show that Foxa3 is the dominant regulator of GLUT expression in the liver, suggesting that reduced efflux of glucose from hepatocytes contributes to the relative …
WebNational Center for Biotechnology Information WebFOXA3 is a transcription factor involved in the macrophage cholesterol efflux and macrophage reverse cholesterol transport reducing the atherosclerotic lesions. Thus, the present study aimed...
WebFeb 1, 2014 · Methods: FOXA3 was identified in airways from patients with asthma and chronic obstructive pulmonary disease. We produced transgenic mice conditionally expressing Foxa3 in airway epithelial cells and developed human bronchial epithelial cells expressing Foxa3. flipkart create new registrationWebOct 8, 2015 · Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. greatest common factor of 35 84 and 91WebJul 1, 2024 · FOXA3 is induced by ER stress and transcriptionally activated by XBP1s. • FOXA3 overexpression or knockout affected TM-induced lipid accumulation. • FOXA3 deficiency in liver ameliorates diet- or genetic-induced NAFLD. • FOXA3 directly regulates Per1 transcription to govern lipid synthetic genes. • greatest common factor of 34 and 9WebJun 24, 2011 · These studies suggest that FOXP3 + macrophages can support and promote tumour growth. In summary, this study describes a unique population of … greatest common factor of 36 42WebJul 1, 2024 · FOXA3 exacerbates the excessive lipid accumulation caused by the acute ER-inducer TM, whereas FOXA3 deficiency in hepatocytes and mice alleviates it. Importantly, FOXA3 deficiency in mice reduced diet-induced chronic ER … flipkart coupons how to useWebFOXA3. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. Assigned HPA protein class (es) for the encoded ... greatest common factor of 35 42WebForkhead box A3 (FOXA3), a members of FOX family, plays critical roles in metabolic homeostasis, while its possible functions in ER stress and fatty liver progression are unknown. Methods FOXA3... flipkart credit card offers